Antimicrobial Stewardship Protocols

If you do not have access to any of the reference or resource documents listed on our site and would like a copy, please reach out to our team via email.

Clinical Pathways and Guidance

Guidelines for Initial Therapy for Common Pediatrics Infections (PDF) (Updated 9/2025)

Febrile Infants

Fever in Infants (8 to 21 days old) Pathway (PDF)

Intra-abdominal Infections

Appendicitis Antibiotic Selection Guideline

NICU Necrotizing Enterocolitis (NEC) Antibiotic Selection (PDF)

Oncology/Stem Cell Transplant

Acute Leukemia Antimicrobial and Antifungal Prophylaxis Guidelines (PDF)

Fever and Neutropenia Guidelines in Pediatric Oncology (PDF)

Prolonged Fever and Neutropenia Pathway (PDF)

Stem Cell Transplant Viral Prophylaxis and Treatment Pediatric Practice Guidelines

Respiratory Tract Infections

Pediatric ARTI

Educational Lectures

Tuberculosis Resources:

Sepsis

NICU Late Onset Sepsis Algorithm

OB Serious Infection & Sepsis Pathway (PDF)

Pediatric Sepsis and Septic Shock Pathway (PDF)

Skin & Skin Structure

Skin and Soft Tissue Infections  (PDF)

Surgical Prophylaxis Guidelines:

LPCH Surgical Prophylaxis Guideline

Perioperative Surgical Antibiotic Prophylaxis (Intraop Dosing) (PDF)

Antibiotic Prophylaxis in ECMO Patients: Cannulation in Sterile Setting and Cannulation in Non-Sterile Setting

Antibiotic-Loaded Bone Cement

ENT and Plastics Peri-Operative Antibiotic Prophylaxis Guidelines (PDF)

Liver Transplant Post-Op Antimicrobial Selection & Duration

Obstetrics: Pre-Incision Antibiotics for Cesarean Delivery Algorithm (PDF) and REDCap Decision Support Tool

ASHP Surgical Prophylaxis Guideline

Urinary Tract Infections

Neonatal and Young Infant (7-60 day) Urinary Tract Infection Pathway (PDF)

Urinary Tract Infections

Antimicrobial Dosing and Monitoring

Aminoglycoside Guideline and Aminoglycoside dosing strategy selection

Antimicrobial Monitoring Guidelines (PDF) (Updated 10/2025)

Amoxicillin-clavulanate (Augmentin®) Dosing Guide (PDF)  (Updated 1/2025)

Azole Antifungal Therapeutic Drug Monitoring Guidance (PDF)

Housestaff Manual

LPCH Blue Card – Antibiogram and Antimicrobial Dosing Quick Reference Card (PDF)

Pediatric Renal Antibiotic Dosing Recommendations

Prolonged Infusion of Beta-Lactam Guidelines (PDF)

Vancomycin per Pharmacy

• Vancomycin Guideline for Neonates and Children
• Vancomycin Guideline for Obstetric Patients
• Vancomycin Guideline in Hemodialysis
• Initial Vancomycin Dosing Guideline for Surgical Patients up to 1 Week Post-op
• ASHP Vancomycin Therapeutic Monitoring Guidelines

Antibiotic Allergy

Antibiotic Desensitization Protocol

Antibiotic Graded Challenge Protocol

Allergy Clinical Decision Support Tool

• Antibiotic Allergy Clinical Decision Support Tool 
• Antibiotic Allergy Tool – Rationale Document  (PDF)
• Antibiotic Allergy Tool Instructions Powerpoint (PPTX)
• Video Tutorial

Antimicrobial Restrictions

List of restricted antimicrobials at LPCH 

ASP Restricted Antimicrobial Approval Process

ASP Restricted Antimicrobial Monographs

Immunizations

LPCH Immunization Guidelines

RSV Infant Prophylaxis:

• Nirsevimab (Beyfortus®) Guideline
• Nirsevimab Monoclonal Antibody Memo (PDF)
• AAP Nirsevimab Frequently Asked Questions

COVID-19 Resources

Vaccination

COVID-19 Vaccine 2025-2026 Memo (PDF)

Treatment

COVID-19 Inpatient Treatment Algorithm

LPCH Therapies for High-Risk Nonhospitalized Patients with Mild to Moderate COVID-19