Pediatric Radiology Clinical Trials and Research

Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. Our current clinical trials at Lucile Packard Pediatric Urology is listed below. 

Lower Urinary Tract Symptoms

Lower urinary tract symptoms (LUTS) refer to a set of conditions involving the abnormal filling and emptying of the bladder, presenting as daytime and nighttime accidents, sudden uncontrollable urge to urinate or increased frequency of peeing without any associated infection. It is a common problem that causes disruptions in school and home settings for many children.

Treatment of LUTS is termed as urotherapy. It is non-invasive and involves education on healthy lower urinary tract (LUT) function with individually tailored recommendations on behavioral and lifestyle modifications. Most children get better with just urotherapy and rarely require any further investigations or medications.

Learn more about our lower urinary tract symptoms research >


Hydronephrosis is ‘swelling’ of the kidney due to a back-up of urine. This can be caused by a blockage in the ureter, which is the tube that drains the kidney, by vesicoureteral reflux, or many other causes. Sometimes the hydronephrosis goes away on its own, but sometimes the hydronephrosis persists and could potentially lead to kidney damage due to pressure on the kidney.

Some children with certain types of hydronephrosis, such as that caused by ureteropelvic junction obstruction (UPJ obstruction), undergo surgery to prevent kidney damage. However not every child with UPJ obstruction will need to have surgery.

Learn more about our hydronephrosis research >